我院门诊静脉应用抗菌药物引起不良反应因素分析

目的:找出影响我院门诊静脉应用抗菌药物引起不良反应的主要因素,从而制定相关对策并进行干预。方法:将我院2006年3月~2007年3月门诊静脉应用抗菌药物病例分为试验组(有药品不良反应)和对照组(随机抽取无药品不良反应),各为105例。从患者因素、处方及护理因素、发药因素等方面进行统计分析,找出有显著性差异的因素。结果:影响门诊静脉应用抗菌药物引发不良反应的主要因素为选用药物的适应证、静脉滴注速度、给药剂量、给药间隔是否合理,是否联合用药,有无用药指导。结论:我院门诊静脉应用抗菌药物存在一些不合理性,需进一步干预。

Analysis of Factors Influencing ADR in the Intravenous Use of Antibiotics in Outpatients

OBJECTIVE： To analyze the chief factors influencing the adverse drug reactions （ADR） in outpatient use of antibiotics so as to formulate corresponding policies for intervention. METHODS： The patients who had been treated i.v with antibiotics from Mar. 2006 to Mar. 2007 were enrolled： 105 in trial group showed ADR, another 105 in control group showed no ADR. The ADR influencing factors were compared between the two groups from aspects of patients, nursing, and medication to find out the significant differences. RESULTS： The chief factors influencing the adverse drug reactions （ADR） in outpatient use of antibiotics included the indications of drugs, dosage, dosing interval, drug combination, and availability of medication guidance. CONCLUSION： The outpatient intravenous use of antibiotics is far from rational, which needes further intervention.