Ontogeny of 3H-muscimol binding to membranes of chick forebrain |
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Authors: | M. G. Stewart R. C. Bourne |
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Affiliation: | (1) Brain Research Group, Department of Biology, The Open University, MK7 6AA Milton Keynes, UK |
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Abstract: | Summary A potent GABA agonist, 3H-muscimol, was used to investigate the development of GABA receptors in left and right hemispheres of chick forebrain from day 12 in ovo to day 21 post-hatch. Total specific 3H-muscimol binding (p mol mg–1 protein) increases rapidly in ovo, reaching a peak at around day one post-hatch and then showing a slow decline to approximately 50% of the maximal level at day 21 post-hatch. Despite the considerable evidence from previous studies of lateralization of avain brain function, no significant hemispheric differences were found in 3H-muscimol binding (either of p mol hemisphere–1 or p mol mg protein–1) at any of the developmental ages examined. |
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Keywords: | 3H-muscimol binding Chick forebrain Hemisphere Development |
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