| 去甲肾上腺素影响单核细胞抗原提呈的机制 |
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| 引用本文： | 周宝宏,龚非力.去甲肾上腺素影响单核细胞抗原提呈的机制[J].免疫学杂志,1993,9(4):227-229. |
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| 作者姓名： | 周宝宏 龚非力 |
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| 作者单位： | 同济医科大学免疫学教研室，同济医科大学免疫学教研室，同济医科大学免疫学教研室，同济医科大学免疫学教研室，同济医科大学免疫学教研室 武汉 430030，武汉 430030，武汉 430030，武汉 430030，武汉 430030 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | １０＾－１３～１０＾－９ｍｏｌ／Ｌ的去甲肾上腺素体外作用时能促进人外周血单核细胞的抗原提呈功能（ＡＰＦ）。ＰＫＣ激活剂ＰＭＡ和抑制剂４ａ－ＰＤＤ分别能加强和抑制ＮＥ对Ｍｏｎ的ＡＰＦ的促进作用；异搏定能抑制ＮＥ的这种作用，而ＰＫＡ的抑制剂ＰＫＩ对ＮＥ的这种作用无。结果提示ＮＥ促进ＭｏｎＡＰＦ的机制可能涉及到Ｃａ＾２＋和ＰＫＣ，而与ＰＫＡ无关。
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| 关 键 词： | 去甲肾上腺素 单核细胞 抗原 |
Mechanism of the Norepinephrine Effect on the Antigen-Presenting Function of Monocytes |
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| Zhou Baohong iGong Feili Feng Xintvei,Xtt Yang,Xiong Ping.Mechanism of the Norepinephrine Effect on the Antigen-Presenting Function of Monocytes[J].Immunological Journal,1993,9(4):227-229. |
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| Authors: | Zhou Baohong iGong Feili Feng Xintvei Xtt Yang Xiong Ping |
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| Abstract: | Antigen-presentin function (APF) of human monocles (Mon) was found to be promoted by norepinephrineCNEilO I3-10 mol/L)in vitro .Activator of PKC(phorbol-12-myristate-13-acetate,PMA) and inhibitor of PKC(4o-phorbol-12-13-didecanoate,4a-PDD)could enhance or depress the promotive effect of NE on the APF of Mon.respectively. Verapamil was found to inhibit the promotive effect of NE as well. whereas inhibitor of PKACProtein Kinase Inhibitor.PKDexerted no influence on the NE effect. These results suggest that Caz, and PKC but not PKA are implicated in the mechanism of the NE effect on the APF of Mon. |
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| Keywords: | Norepinephrine Monocyte Antigen presentation Protein kinase A Ca~(2-) |
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