| 常通口服液对大鼠实验性肠粘连的实验研究 |
| |
| 引用本文： | 王春霞,侯连兵. 常通口服液对大鼠实验性肠粘连的实验研究[J]. 中药材, 2004, 27(4): 272-274 |
| |
| 作者姓名： | 王春霞 侯连兵 |
| |
| 作者单位： | 第一军医大学南方医院,广州,510515 |
| |
| 基金项目： | 国家新药研究基金(编号 :96 90 1 0 5 2 45 ) |
| |
| 摘 要： | 目的 :研究常通口服液对实验性肠粘连大鼠的防治效果。方法 :选用SD雄性大鼠 ,手术造成肠粘连模型。各组治疗 7天后取血 ,测定TNF α含量 ,并记录大鼠肠粘连级别。结果 :模型组的TNF α含量与正常组比较有显著性差异 (P <0 0 0 1) ,常通口服液低、中、高剂量组与模型组比较均能显著降低TNF α含量 (P <0 0 0 1)。结论 :常通口服液能降低术后肠粘连级别和血清中TNF α含量。提示常通口服液对大鼠肠粘连具有良好的防治作用
|
| 关 键 词： | 常通口服液 肠粘连 TNF-α |
| 修稿时间： | 2003-07-22 |
Experimental Research on the Effects of "Chang Tong Oral Liquid"on Experimental Intestinal Adhesion in Rats |
| |
| Wang Chunxia ,Hou Lianbing. Experimental Research on the Effects of "Chang Tong Oral Liquid"on Experimental Intestinal Adhesion in Rats[J]. Journal of Chinese medicinal materials, 2004, 27(4): 272-274 |
| |
| Authors: | Wang Chunxia Hou Lianbing |
| |
| Affiliation: | First Military Medical University, Guangzhou 510515. |
| |
| Abstract: | OBJECTIVE: To study the efficacy of "chang tong oral liquid" (CTOL) on the degree of intestinal adhesion in rats after surgery. METHODS: SD rat model of intestinal adhesion was made by surgery. After each group was treated continuously for 7 days, serum TNF-alpha level was determined and the degree of intestinal adhesion was graded. RESULTS: There was a significant difference between the level of TNF-alpha in model group and those in normal group (P < 0.001). The level of TNF-alpha was remarkably decreased by small, medium and big dose of CTOL, as compared with that of model group (P < 0.001). CONCLUSION: CTOL can significantly decrease the graded scores of intestinal adhesion and serum TNF-alpha level. It suggested that CTOL could cure adhesion of intestine in rats. |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
