呼吸道合胞病毒毛细支气管炎特应性与血清IL-10及病情恢复的关系

为探讨呼吸道合胞病毒(RSV)毛纫支气管炎患儿特应性与血清白介素10(IL-10)水平及病情恢复的关系，应用酶联免疫吸附法分别检测17例年龄50天--12月，特应性体质的RSV毛细支气管炎患儿急性期与恢复期血清IL-l0水平，并以24例非特应性患儿及37例正常儿为对照组。结果显示，急性期待应性组IL—10水平与正常对照组相比，差异无显著性(P＞0．05)，但明显低于无特应性组(P＜0．001)；特应性组喘憋和肺部体征消失均较非特应性组慢，住院时间延长(P＜0．05)；恢复期两组IL-l0差异无显著意义。提示特应性体质患儿RSV感染后不能上调IL-l0产生，结果可导致病变恢复缓慢。

Primary study on the relationship between atopy dynamic changes of the serum IL-10 level and the recovery of the disease in infants with the respiratory syncytial virus bronchiolitis

To explore the relationship between atopy,dynamic changes of the serum IL-10level and the recovery of the disease in infants with the respiratory syncytial virus(RSV)bronchiolitis,serum IL-10levels were assayed with ELISA in17infants with atopy in the acute stage and recovery stage of the RSV bron-chiolitis.24infants without atopy and37normal infants were enrolled as the control group.The results showed serum IL-10levels in the acute stage of the infants with atopy were no significant difference(P>0.05)in comparison with that of normal control group,but markedly lower than that in the infants without atopy(P< 0.001).The speed for disappearance of the wheezing and the pulmonary signs in the infants with atopy was slower than that in infants without atopy and the time of hospitalization was also longer than that in infants without atopy(P<0.05).There were no difference of serum IL-10levels between these two groups in the re-covery stage,indicating that the production of IL-10couldn't be upregulated in infants with atopy when they had RSV infection,and could subsequently result in the slower recovery of the symptoms and signs.