维生素D及其受体与毛发的关系

背景：越来越多的研究发现,维生素D及其受体与毛发有一定关系。 目的：全面阐述维生素D及其受体与毛囊干细胞、毛发生长周期、信号转导以及脱发性疾病等的关系。 方法：应用计算机以“维生素D、维生素D受体、毛发、脱发、基因多态性”或“vitamin D,vitamin D receptor,hair,alopecia,gene polymorphism”为检索词检索PubMed和CNKI数据库1990/2011-11发表的关于维生素D及其受体与毛发关系的文章,同一领域选择近期发表或发表在权威杂志上的文章。 结果与结论：初检得到152篇文献,根据纳入排除标准选择30篇文章进行综述。目前研究显示,维生素D及其受体在毛发中扮演重要角色,其异常可导致脱发等疾病的产生,为预防和治疗脱发性疾病提供新的可能,并有望在未来广泛应用。关键词：维生素D;维生素D受体;毛发;脱发;基因多态性;毛囊干细胞 doi:10.3969/j.issn.1673-8225.2012.14.035

Relationship between vitamin D,vitamin D receptor and hair

BACKGROUND: Increasing evidence has demonstrated that vitamin D and its receptor correlate with hair. OBJECTIVE: To fully discuss the relationship between vitamin D, vitamin D receptor and hair follicle stem cells, hair cycle, signal transduction and alopecia. METHODS: A computer online retrieval was performed in PubMed and CNKI database to search papers addressing the relationship between vitamin D, vitamin D receptor and hair published between November 1990 and November 2011 with the key words “ vitamin D, vitamin D receptor, hair, alopecia, gene polymorphism” in Chinese or English. Papers published recently or in the authoritative journals were selected. RESULTS AND CONCLUSION: A total of 152 papers were initially retrieved. According to inclusion and exclusion criteria, 30 papers were selected. The current studies have shown that vitamin D and its receptor play an important role in hair and the disorder of vitamin D would lead to alopecia. Regulation of vitamin D and its receptor may be successful in preventing and treating hair disorders and is promising in future use.