| 抗结核药物性肝损害易感基因研究进展 |
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| 引用本文： | 朱冬林 席云 吴雪琼. 抗结核药物性肝损害易感基因研究进展[J]. 中国人兽共患病杂志, 2012, 28(2): 172-174 |
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| 作者姓名： | 朱冬林 席云 吴雪琼 |
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| 作者单位： | 1. 中山大学附属第三医院2. 解放军第309医院 |
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| 基金项目： | “重大新药创制”科技重大专项资助项目;北京市科技计划研发攻关类科研基金资助项目 |
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| 摘 要： | 药物性肝损害是结核病正规化疗过程中最为常见的不良反应，也是结核病患者停止化疗的最常见原因之一。国内外有大量报道称抗结核药物性肝损害的发生与机体药物代谢酶基因多态性相关。本文对抗结核药物肝损害发生的分子机制研究的国内外进展情况进行概要地介绍，旨在从基因水平上了解抗结核药物性肝损害易感因素。
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| 关 键 词： | 抗结核药物 肝损害 基因多态性 Antituberculosis drug Liver injury Genetic polymorphisms |
| 收稿时间： | 2011-05-04 |
Research progress on the susceptible genes of antituberculosis drug-induced liver injury |
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| Abstract: | Antituberculosis drug-induced liver injury (ATDLI) is the most common adverse reaction in regular chemotherapy process of tuberculosis，and also is one of the most common causes of discontinuous treatment in TB patients. The relationship between ATDLI and of drug metabolizing enzymes had been reported in many researches. This paper reviewed the research progress of the molecular mechanisms in ATDLI, to realize the susceptible factors of antituberculosis drug-induced liver injury in gene level. |
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