具有生物活性的高导复合支架材料制备表征及其生物相容性☆

背景：组织工程新材料必须既能支持组织生长，又能激发理想的细胞反应(如血管发生)，而导电性则可促进包括神经在内的组织再生。目的：构建一种新型材料，能将导电性和生物活性有效的结合起来，为组织工程提供一种理想的备选材料。方法：将具有生物活性的透明质酸多糖和导电聚合物聚吡咯进行结合，制备具有生物活性的导电聚合物复合材料。结果与结论：含有透明质酸多糖的聚吡咯/透明质酸双层膜具有光滑的表面形貌和良好的导电性。体外细胞相容性实验显示这种复合材料可显著促进神经轴突的延伸。体内实验显示该复合材料还具有良好的惰性和促血管生成效应，是一种较为理想的组织工程备选材料。

Preparation,characterization and biocompatibility of high-conductivity compound scaffolds containing biological activity

BACKGROUND: New materials of tissue engineering can not only support the growth of tissues but also stimulate ideal cell response such as angiogenesis. Its conductivity can promote tissue regeneration included nerve.OBJECTIVE: To prepare a new type of material that combines conductivity and biological activity as an ideal type of alternative material for tissue engineering.METHODS: The bioactive polysaccharide hyaluronic acid (HA) was combined with the conductive polymer polypyrrole (PPy) to prepare conductive polymer composites containing biologically activity.RESULTS AND CONCLUSION: PPy/HA bilayer films had the characters of smooth and conductivity. Cell compatibility experiments in vitro showed that the composites could promote the extension of axons. The composites had verified to have a good inertia and can promote the vascularization in vivo. PPy/HA composite biomaterials are suitable for tissue engineering.