雌激素受体α基因TA重复序列多态性与南昌市绝经后妇女骨密度的相关性研究

探讨雌激素受体α(ERα)基因TA重复序列多态性与南昌市绝经后妇女骨密度的相关性。方法选取符合调查要求的南昌市100名绝经后妇女为研究对象,收集其基本资料,通过双能X线吸收法测量骨密度(bonemineral density,BMD)(根据骨密度分为骨质疏松组40例和非骨质疏松组60例),用测序方法检测重复序列多态性TA重复次数,最后进行统计学分析。结果 TA12等位基因在骨质疏松组和非骨质疏松组之间分布频率不同,骨质疏松组TA12等位基因频率为7.50%,低于非骨质疏松组(26.67%),差异有统计学意义(P=0.019)。结论 TA12等位基因可能是骨质疏松的保护性基因。

Relationship between ERα Gene TA Repeat Sequence Polymorphism and Bone Mineral Density in Postmenopausal Women in Nanchang City

Objective To investigate the relationship between estrogen receptor alpha(ERα) gene TA repeat polymorphism and bone mineral density(BMD) in postmenopausal women in Nanchang city.Methods A total of 100 postmenopausal women in Nanchang were selected according to the requirement for investigation and were divided into osteoporosis group(n=40) and non-osteoporosis group(n=60).Basic data of subjects were collected.The BMD was measured by dual energy X-ray absorptiometry and TA repeat sequence polymorphism was detected by sequencing.Results TA12 allele frequency in osteoporosis group was significantly lower than that in non-osteoporosis group(7.50% vs 26.67%,P=0.019).Conclusion TA12 allele may be the protective gene in osteoporosis.