胆囊收缩素对大鼠坐骨神经损伤后修复的影响

探讨八肽胆囊收缩素用于大鼠坐骨神经损伤后修复的效果。方法将24只大鼠建立坐骨神经损伤模型。模型建立成功后,将24只大鼠按不同的给药方法分为2组:八肽胆囊收缩素组(实验组)和对照组,每组12只。实验组给予八肽胆囊收缩素8nmol·kg-1腹腔注射,1次·d-1;对照组给予生理盐水8nmol·kg-1腹腔注射,1次·d-1。2组大鼠均连用7d。并对2组大鼠术后4周进行电生理检测,检测坐骨神经复合神经动作电位(CNAP)、感觉神经动作电位(SNAP)和腓肠肌复合肌肉动作电位(CMAP),分别记录潜伏期(LAT)、波幅(AMP)和神经传导速度(NCV)。结果术后4周,实验组CNAP、SNAP、CMAP的LAT差值及AMP、NCV恢复率与对照组比较差异均有统计学意义(P<0.05或P<0.01)。实验组大鼠腓肠肌肌电图波幅高,潜伏期短。结论八肽胆囊收缩素能有效地促进周围神经损伤后的修复。更多还原

Effect of Cholecystokinin Octapeptide on Recovery after Sciatic Nerve Injury in Rats

Objective To explore the effect of cholecystokinin octapeptide on recovery after sciatic nerve injury in rats.Methods A model of sciatic nerve injury was established in 24 rats.These rats were assigned to receive intraperitoneal injection of either 1 nmol·kg-1 of cholecystokinin octapeptide(experiment group,n=12) or 8 nmol·kg-1 of isotonic saline(control grup,n=12) for 7 days.Compound nerve action potential(CNAP) and sensory nerve action potential(SNAP) of sciatic nerves and compound muscle action potential(CMAP) of gastrocnemius muscles were detected by an electromyography recorder postoperative 4 weeks.The latency(LAT),amplitude(AMP) and nerve conduction velocity(NCV) were recorded.Results Postoperative 4 week,LAT difference values of CNAP,SNAP and CMAP and recovery rates of AMP and NCV in experiment group were significantly different from those in control group(P<0.05 or P<0.01).The gastrocnemius electromyography of volatility high and incubation period short in experiment group.Conclusion Cholecystokinin octapeptide can promote the recovery after peripheral nerves.