Wnt/β-连环蛋白信号通路在骨关节炎发生过程中的作用**

背景：研究表明经典Wnt/β-连环蛋白信号通路与骨关节炎的发生发展有重要联系,Wnt蛋白家族、β-连环蛋白以及相关抑制因子可以调节软骨细胞功能和代谢。 目的：综述Wnt/β-连环蛋白信号通路与骨关节炎的关系。 方法：通过计算机检索 CNKI 和Elsevier数据库中2000/2011文献,关键词为“Wnt/β-catenin,OA,骨关节炎,软骨细胞”。选择与Wnt/β-连环蛋白信号通路对骨关节炎影响有关的文章内容。 结果与结论：目前研究表明经典Wnt/β-连环蛋白信号通路是维持关节完整性,调节关节软骨代谢的重要途径之一,对骨关节炎有重要影响。Wnt信号通路以及下游信号OPG/RANKL/RANK通过调节和控制关节软骨代谢,引发骨关节炎疾病,但具体机制有待进一步研究。研究Wnt通路的组分及其作用,不仅有助于骨关节炎的特定治疗,而且有利于预防骨质疏松及其他关节性疾病。 关键词：软骨代谢;Wnt/β-连环蛋白;信号通路;骨关节炎;软骨细胞 doi:10.3969/j.issn.1673-8225.2012.13.029

Role of Wnt/beta-catenin signal pathway in the occurrence of osteoarthritis

BACKGROUND: Studies have shown that the classical Wnt/β-catenin signal pathway is closely related to the occurrence and development of osteoarthritis. Wnt protein family, β-catenin and related inhibitors can regulate the function and metabolism of chondrocytes. OBJECTIVE: To summarize the relationship between Wnt/β- catenin signal pathway and osteoarthritis. METHODS: A computer online search was performed to fine papers published between 2000 and 2011 in CNKI database and PubMed database. The key words of “Wnt/β-catenin, OA, osteoarthritis, cartilage cells” were used. Documents concerning the effects of Wnt/β- catenin signal pathway on osteoarthritis were included. RESULTS AND CONCLUSION: Currently, studies show that the Wnt/β- catenin signal pathway is one of the important way to restrain the integrity of joint and regulate the metabolism of bone joint, can influence the osteoarthritis. Wnt signal pathway and its downstream signal osteoprotegerin/receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B can regulate and control the articular cartilage metabolism result in osteoarthritis. However, the specific mechanism is still unclear. The research of components and effect of Wnt signal pathway are important for the special treatment of osteoarthritis and the prevention of osteoporosis or other diseases.