右美托咪啶对双腔支气管内插管血流动力学的影响

目的 观察右美托咪啶用于抑制双腔支气管内插管诱发患者心血管反应的效果。方法 择期全身麻醉下行肺或食道手术的患者30例，ASA I~II级，年龄18-65岁，体重50-80kg，随机分为2组：对照组（C组，n=15）和右美托咪啶组（D组，n=15），在麻醉诱导前D组静脉泵注右美托咪啶1μg/kg，泵注时间为15min，C组静脉泵注与D组等容量、等时间的生理盐水。分别于输注右美托咪啶前（T0）、气管插管前（T1）、气管插管时（T2）、气管插管后1、3、5、10min（T3-T6）时记录患者的血压及心率变化。结果 与C组比较，D组HR在T1时点差异性有统计学意义（P＜0.05）；与C组比较，D组HR、SBP及DBP在T2-T5时点差异性有统计学意义（P＜0.05）；与C组比较，D组HR、SBP及DBP在T6时点差异无统计学意义（P>0.05）。结论 1μg/kg的右美托咪啶麻醉前泵注能够抑制双腔气管导管插管时的心血管反应。

Effects of dexmedetomidine in inhibition of cardiovascular response to double-lumen endobronchial intubation

Objective To observe the dexmedetomidine in inhibition of cardiovascular response to double-lumen endobronchial intubation. Methods Thirty ASA I ~ II patients, aged 18-65 years, weighing 50-80kg, scheduled for lung or esophageal surgery were randomly assigned to two groups: control group (C group, n=15) and dexmedetomidine group (D group, n=15), group D was given dexmedetomidine 1μg/kg before anesthesia induction, infusion time was 15min; group C was given 10ml saline instead of dexmedetomidine. BP and HR were recorded before infuse of dexmedetomidine(T0), before intubation (T1), immediately after intubation (T2) and at 1,3,5,10 min after intubation (T3-T6). Results Compare with C group, HR was significantly decreased at T1 in group D(P <0.05); HR, SBP and DBP were lower at T2-T5 in group D (P <0.05); HR, SBP and DBP were no difference at T6 in group D (P>0.05). Conclusion 1μg/kg dexmedetomidine infusion before anesthesia may effectively inhibit double-lumen endotracheal tube intubation cardiovascular responses.