Malignancies arising in endometriosis |
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| Institution: | 1. School of Mathematics and Computer Science, Fujian Normal University, Fuzhou, China;2. Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, USA;3. Department of Computer Science, University of Sherbrooke, Sherbrooke, Canada;1. School of Information Science and Engineering, Lanzhou University, Lanzhou, China;2. College of Computer Science and Technology, Zhejiang University, China;3. School of Physical Science and Technology, Lanzhou University, Lanzhou, China |
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| Abstract: | Malignant transformation of endometriosis is a well-documented process with over 300 cases presented in the literature. The majority of these cases arise in ovarian endometriosis; however, approximately 25% are found in extragonadal sites. Although not definitely proven, a theory has been proposed in several reports that the use of unopposed estrogen in women with a history of endometriosis who have undergone hysterectomy may be a contributing factor. Several of these studies have therefore suggested the addition of a progestational agent for these women. Endometriotic implants share not only a common histology with the endometrium, but also similar function and responsiveness to the hormonal milieu. As in the case of women with a uterus, and consequently an endometrium, the use of unopposed estrogen may present a risk factor for malignant transformation of endometriosis. Diagnosis and treatment of these malignancies is based on tumor location and histology, similar to analogous malignancies of the uterus and ovaries. |
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