自体骨髓干细胞移植治疗下肢缺血性疾病☆

背景：骨髓干细胞可通过多种机制促进缺血下肢新生血管生成，形成新的侧支，改善局部血供。目的：总结骨髓干细胞在下肢缺血性疾病中的研究进展。方法：应用计算机检索PubMed及CNKI数据库2001-12/2011-12与骨髓干细胞移植治疗下肢缺血性疾病相关的文献，检索词“bone marrow stem cells，lower extremists ischemia”。结果与结论：骨髓干细胞可定向到达坏死组织参与组织再生，形成和分泌许多血管活性生长因子促进血管新生，促进细胞增殖和分化，利于组织细胞再生。关于骨髓干细胞移植治疗下肢缺血性疾病方面的研究虽已取得较大进展，但仍存在许多问题，如种子细胞的保存，细胞体外培养中分化增殖的调控机制不十分清楚，产生骨骼肌细胞的生物力学性能不太满意，修复组织内细胞分子生物学特性不明确等。

Autologous bone marrow stem cells transplantation in the treatment of lower limb ischemia

BACKGROUND: Bone marrow stem cells can promote the ischemic limb angiogenesis, the formation of new collateral vessels, and improve local blood supply through a variety of mechanisms. OBJECTIVE: To review the effect of bone marrow stem cells transplantation in the treatment of lower limb ischemia.METHODS: PubMed and CNKI were retrieved using computer to search relevant articles published from December 2001 to December 2011, and the keywords were “bone marrow stem cells, lower extremists ischemia”.RESULTS AND CONCLUSION: Bone marrow stem cells can migrate to the site of lower limb ischemia, and participate in tissue regeneration, formation and secretion of many vasoactive growth factors to promote angiogenesis, promote cell proliferation and differentiation, which are conducive to tissue and cell regeneration. However, there are still many questions to be solved, such as preservation of seed cells, regulatory mechanism of cell differentiation and proliferation in vitro, biomechanical properties of skeletal muscle cells, cellular and molecular biological characteristics of cells in repaired tissues.