肾移植与免疫抑制剂的应用研究：SCI数据库2001/2010年收录文献检索分析

背景：免疫用药在肾移植中占有重要的作用,免疫抑制剂的效应会影响肾移植后人/肾的存活及移植后患者的生活质量。 目的：分析SCI数据库肾移植与免疫抑制剂应用研究文献的相关数据,以期得出国际肾移植与免疫抑制剂的研究状况及发展趋势。 设计：文献计量学分析。 资料提取：以电子检索方式检索SCI数据库2001-01/2010-12有关肾移植与应用免疫抑制剂研究的文献,采用检索词为“renal transplant/kidney transplant(肾移植),immunosuppression(免疫抑制剂),azathioprine/Aza(硫唑嘌呤),cyclosporin A/CsA(环孢素A),rapamycin/sirolimus(雷帕霉素),mycophenolate mofetil(霉酚酸酯),tacrolimus/FK506(他克莫司)”。将SCI数据库中自带的分析功能和Excel软件的绘图功能相结合,从文献类型、时间分布、国家或地区分布、基金资助机构分布、出版物分布和文献被引频次分布,发表文献作者等方面对肾移植与免疫抑制剂应用研究相关文献进行统计和计量分析,描述其分布特征。 入选标准：纳入标准：①同行评议的肾移植与免疫抑制剂应用研究密切相关的研究原著。②肾移植与免疫抑制剂应用研究相关的综述。③肾移植与免疫抑制剂应用研究相关的会议记录及摘要。④肾移植与免疫抑制剂应用研究相关的快报文章。⑤肾移植与免疫抑制剂应用研究相关的编辑素材。排除标准：①与文章目的无关的文献。②大于10年较陈旧的文献。③未发表的文章。④需电话追踪和手工检索逐一分析的文章。 主要数据判定指标：①文献类型分析。②文献出版时间趋势。③国家或地区分布。④基金资助机构分布。⑤来源出版物特点。⑥文献被引频次情况。⑦发表文献的作者分布。⑧肾移植与5种免疫抑制剂应用的文献对比。 结果：①SCI数据库2001/2010收录的文献中共检索到6 224篇肾移植与免疫抑制剂应用相关的文献,研究原著以5 038篇位居首位,其中有22篇可以确定为经典文献。②在时间分布上文献数量2001/2005呈逐年上升趋势,2006/2010呈下 降趋势。③美国国立卫生研究院资助文献数量为49篇。④《移植学会会报》发表此类文献914篇,处于领先地位,其次为《移植》杂志发表777篇、《美国移植杂志》发表535篇,《移植学会会报》为该领域的核心期刊。 结论：文献分析显示了肾移植与免疫抑制剂应用研究这一领域国际文献出版情况的发展趋势,可为学科专家深入研究肾移植与免疫抑制剂的应用研究提供可借鉴的参考建议。 

Immunosuppressant medicines for renal transplantation: A literature analysis based on Science Citation Index database from 2001 to 2010

BACKGROUND: Immunosuppressive medication plays an important role in renal transplantation. The use of immunosuppressant medicine for renal transplantation will affect survival of humans/kidneys after kidney transplantation as well as patient’s quality of life. OBJECTIVE: The literature regarding various immunosuppressant medicines for renal transplantation in Science Citation Index (SCI) database was analyzed to understand the trends of studies on immunosuppressant medicine for renal transplantation. DESIGN: Bibliometric analysis. DATA RETRIEVAL: A retrieval was performed for the literature of various immunosuppressant medicines for renal transplantation, including azathioprine/ Aza, cyclosporin A/CsA, rapamycin/sirolimus, mycophenolate mofetil and tacrolimus/FK506 during 2001-01 and 2010-12 in SCI. Quantitative analysis was used to analyze the literatures based on their document type, publication time, country, funding agency, citation, and author. SELECTIVE CRITERIA: Articles on immunosuppressant medicine for renal transplantation including the following types: (1) Peer-reviewed original paper; (2)Reviews; (3)Meeting notes and abstracts; (4)Letters; (5)Editorial materials. Exclusive criteria were included (1)Articles unrelated the study of immunosuppressant medicine for renal transplantation; (2)Articles published before 2001; (3)Articles which were not published on journals; (4)Articles which need to be retrieved by phone or manually. MAIN OUTCOME MEASUREMENTS: (1)Document type distribution. (2)Publication time distribution. (3)Country distribution. (4)Funding agency distribution. (5)Journal distribution. (6)Citation frequency. (7)Author output. (8)Comparison of literature  regarding five immunosuppressants for renal transplantation. RESULTS: (1)6 224 papers on immunosuppressant medicine for renal transplantation were retrieved in SCI database, in which most of paper were published as original articles. Twenty-two articles were identified as classic literature. (2)The overall number of literature had an upward trend from 2001 to 2005, and a downward trend from 2006 to 2010. (3)Forty-nine papers were funded by National Institutes of Health (NIH). (4)Transplantation Proceedings published most papers in this field (914), followed by Transplantation (777) and American Journal of Transplantation (535). Transplantation Proceedings was recognized as the core journal in the area. CONCLUSION: The analysis of international literature shows the development of immunosuppressant medicine for renal transplantation, which could provide reference for subject experts to further study unsolved issues in the field.