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| 黄精多糖干预骨质疏松性骨折大鼠白细胞介素1和白细胞介素6的表达 | |
| 作者姓名： | 曾高峰 张志勇 鲁 力 肖德强 宗少晖 熊春翔 赵玉玺 |
| 作者单位： | 广西医科大学， 1公共卫生学院， 3研究生学院，广西壮族自治区南宁市 530021； 2广西医科大学第一附属医院脊柱骨病外科，广西壮族自治区南宁市530021 |
| 基金项目： | 由广西教育厅科研基金(302204)、广西医科大学公共卫生与预防医学博士后基金(308084)资助 |
| 摘 要： | 背景：骨质疏松性骨折主要是由于雌激素减少引发的高转换型骨质疏松并发症，给予雌激素能够得到有效地纠正。
目的：观察黄精多糖对骨质疏松性骨折大鼠细的胞因子的影响。
方法：6月龄雌性SD大鼠行卵巢切除建立骨质疏松症大鼠模型90 d后，锯断胫骨建立骨质疏松性骨折模型。骨折1周后，分别以400，200，100 mg/kg黄精多糖灌胃和0.066 mg/kg雌二醇肌肉注射给药治疗。
结果与结论：相比于一般性骨折大鼠，骨质疏松性骨折大鼠血清白细胞介素1，6的表达升高；400 mg/kg黄精多糖或雌激素干预治疗后，大鼠血清的白细胞介素1，6的表达明显降低(P < 0.05)，但200和100 mg/kg黄精多糖对大鼠血清的白细胞介素1，6的表达没有影响(P > 0.05)，提示黄精多糖干预治疗骨质疏松性骨折需要较高浓度 |
| 关 键 词： | 黄精多糖 骨质疏松 白细胞介素1 白细胞介素6 骨折 |
| 收稿时间： | 2011-07-04 |
Effects of polygonatum polysaccharide on the expression of interleukin-1 and 6 in rats withosteoporotic fracture |
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| Authors: | Zeng Gao-feng Zhang Zhi-yong Lu Li Xiao De-qiang Zong Shao-hui Xiong Chun-xiang Zhao Yu-xi |
| Institution: | 1School of PublicHealth, GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China; 2Departmentof Spine Surgery,First AffiliatedHospital of GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China; 3PostgraduateCollege, GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China |
| Abstract: | BACKGROUND:Osteoporotic fracture is an osteoporotic complication caused by reduced estrogen and can be effectivelycorrected by estrogen supplementation. OBJECTIVE:To investigate the effects of polygonatum polysaccharide (PSP) on cytokines in osteoporotic fracture rats. METHODS:Sprague-Dawley rats, aged 6 weeks old, were established into osteoporosis models by ovariectomy. After 90 days,the tibia was cut off to create models of osteoporotic fracture. At 1 week after osteoporotic fracture, rats were intragastricallyadministered 400, 200, 100 mg/kg PSP and intramuscularly administered estradiol. RESULTS AND CONCLUSION:Compared with common fracture rats, serum level of interleukin 1, 6 was increased inosteoporotic fracture rats. After intervention with 400 mg/kg PSP or estradiol, serum level of interleukin 1, 6 in osteoporotic fracturerats was significantly decreased (P < 0.05), but 200 and 100 mg/kg PSP did not affect |
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