骨形成蛋白信号转导及调控*

背景：骨形成蛋白属于转化生长因子β超家族成员,具有很强的诱导成骨能力。 目的：对骨形成蛋白功能、信号转导及调控机制及其信号通路异常与人类疾病的关系进行综述。 方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2010)Medline(1999/2010)数据库,检索词分别为“骨形成蛋白、骨形成蛋白受体、Smad 蛋白、信号转导、信号调控”和“Bone morphogenetic proteins,Bone morphogenetic proteins receptors, Smads,Signal transduction,Signaling regulation”。从骨形成蛋白的结构与功能,骨形成蛋白信号传导通路及调控,骨形成蛋白信号通路异常与人类疾病3方面进行总结。共检索到110篇文章,按纳入和排除标准对文献进行筛选,共纳入47篇文章。 结果与结论：骨形成蛋白主要通过 Smad 依赖性和Smad 非依赖性2条信号转导途径发挥作用,此过程受到细胞内外许多蛋白的调控,此外骨形成蛋白信号通路异常与人类某些疾病密切相关。

Signal transduction and regulation of bone morphogenetic proteins

BACKGROUND: Bone morphogenetic protein is a member of transforming growth factor β superfamily. It has a strong induction of bone formation. OBJECTIVE: To review the function, signal transduction, signal regulation mechanism of bone morphogenetic proteins and the effect of abnormal signal pathway on human disorders. METHODS: An online search of CNKI and Medline databases was performed for articles published before 2010 (CNKI) or between 1999 and 2010 (Medline) using keywords of “bone morphogenetic proteins, bone morphogenetic proteins receptors, Smads, signal transduction, signaling regulation” in Chinese and English, respectively. Relevant articles were summarized from three aspects of bone morphogenetic protein: the structure and function, the signal transduction pathway and regulation, the relationship between abnormal signal pathway and human disorders. A total of 110 articles were included. According to inclusion and exclusion criteria, a number of 47 articles were retained at last. RESULTS AND CONCLUSION: Bone morphogenetic proteins play roles mainly through two signal transduction pathways, Smad-dependent pathway and Smad-independent pathway. This process is regulated by numerous extracellular and intracellular proteins. Furthermore, abnormal signaling of bone morphogenetic protein is closely related to some human disorders.