| 5-氨基酮戊酸光动力学疗法抗单纯疱疹病毒的实验研究 |
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| 引用本文： | 陶纪宁,段淑敏,李军. 5-氨基酮戊酸光动力学疗法抗单纯疱疹病毒的实验研究[J]. 中华实验和临床病毒学杂志, 2007, 21(1): 79-82 |
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| 作者姓名： | 陶纪宁 段淑敏 李军 |
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| 作者单位： | 1. 201203,上海复旦张江生物医药股份有限公司
2. 中国疾病预防控制中心病毒病预防控制所 |
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| 基金项目： | 上海市科技发展基金项目(01DJGK012) |
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| 摘 要： | 目的研究5-氨基酮戊酸光动力学疗法(ALA-PDT)在体内外抗单纯疱疹病毒(HSV)的作用。方法以HSV-Ⅰ感染豚鼠皮肤的动物模型以及HSV-Ⅰ和HSV-Ⅱ感染的Vero细胞为实验系统,观察ALA-PDT抗单纯疱疹病毒的疗效。结果ALA-PDT在体外具有抑制HSV-Ⅰ和HSV-Ⅱ的作用,与阳性药物无环鸟苷作用基本一致。体内实验中,外用ALA对HSV-Ⅰ型豚鼠皮肤感染仅进行一次PDT治疗,对皮肤病变就产生了剂量依赖性的治疗效果,中、高剂量组疗效显著。结论ALA-PDT能够有效地灭活单纯疱疹病毒,治疗该病毒引发的皮肤病变。为该疗法用于病毒性疾病的治疗提供了依据。
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| 关 键 词： | 光化学疗法 氨基酮戊酸 单纯疱疹病毒属 豚鼠 |
| 收稿时间： | 2006-12-10 |
Experimental studies on treatment of HSV infection with photodynamic therapy using 5-aminoievulinie acid |
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| TAO Ji-ning,DUAN Shu-min,LI Jun. Experimental studies on treatment of HSV infection with photodynamic therapy using 5-aminoievulinie acid[J]. Chinese journal of experimental and clinical virology, 2007, 21(1): 79-82 |
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| Authors: | TAO Ji-ning DUAN Shu-min LI Jun |
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| Affiliation: | Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd, Shanghai 201203, China |
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| Abstract: | Objective To investigate in vitro and in vovo anti-human herpes simplex virus effects of photodynamic therapy(PDT) using 5-aminolevulinic acid(ALA). Methods Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.Results The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.Conclution ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections. |
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| Keywords: | Photochemotherapy Aminolevulinic Acid Herpes simplex virus Guinea Pigs |
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