| 骨髓间充质干细胞对心肌梗死治疗的研究进展 |
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| 引用本文： | 刘金峰,凌斌. 骨髓间充质干细胞对心肌梗死治疗的研究进展[J]. 中国医学科学院学报, 2015, 37(2): 108-112. DOI: 10.3881/j.issn.1000-503X.2015.01.020 |
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| 作者姓名： | 刘金峰 凌斌 |
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| 作者单位： | 昆明医科大学第四附属医院重症医学科,昆明 650051 |
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| 基金项目： | 国家自然科学基金(81360289)和云南省应用基础研究计划项目(40212060) |
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| 摘 要： | 骨髓间充质干细胞拥有心肌再生的能力,移植后能够产生心肌样细胞,促进血管生成,分泌多种生长因子与细胞因子。本文总结了心肌修复的分子机制,探讨了心肌梗死后心肌潜在的再生能力,回顾了以往研究中干细胞移植对心肌梗死后心肌修复的治疗效果,为制定临床策略提供了新的思路。
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| 关 键 词： | 骨髓间充质干细胞 心肌梗死 干细胞移植 |
| 收稿时间： | 2014-08-13 |
Bone Marrow-derived Mesenchymal Stem Cells in the Treatment of Myocardial Infarction |
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| LIU Jin-feng,LING Bin. Bone Marrow-derived Mesenchymal Stem Cells in the Treatment of Myocardial Infarction[J]. Acta Academiae Medicinae Sinicae, 2015, 37(2): 108-112. DOI: 10.3881/j.issn.1000-503X.2015.01.020 |
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| Authors: | LIU Jin-feng LING Bin |
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| Affiliation: | Department of Intensive Care Unit, the 4th Affiliated Hospital, Kunming Medical University, Kunming 650051, China |
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| Abstract: | Bone marrow-derived mesenchymal stem cells(BMSCs)have the ability to regenerate myocadial tissue. BMSCs transplantation can produce cardiac-like cells,promote angiogenesis,and secrete a variety of growth factors and cytokines. This article summarizes the molecular mechanisms of myocardial repair,explores the potential regenerative capacity of cardiac muscles after myocardial infarction,and reviews the previous studies on BMSC transplantation for treatment of cardiac muscle after myocardial infarction,with an attempt to provide new insights in clinical decision-making. |
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| Keywords: | bone marrow-derived mesenchymal stem cells myocardial infarction stem cell transplantation |
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