容积敏感性氯离子通道在肿瘤中的研究进展

 细胞肿胀后可以激活或上调一系列阴离子通道，在这些容积激活或调节的阴离子通道中，容积敏感性外向整流（VSOR）氯离子通道的激活和表达最显著和常见。先前研究表明，VSOR在肿瘤细胞的容积调节、细胞增殖、分化、迁移、凋亡和耐药等病理生理过程中发挥重要作用，研究还发现许多信号分子参与了VSOR氯离子通道活性的调节，但其分子定位和激活机制尚不清楚。因此，明确其分子定位和激活机制可能会使VSOR氯离子通道成为肿瘤治疗的新靶点。

The research progress of volume-sensitive Cl- channel in tumor

Cell swelling activates or upregulates a number of anion channels. Of the volume-activated or-regulated anion channels, the volume-sensitive outwardly rectifying anion channel (VSOR) is most prominently activated and ubiquitously expressed. Volume regulated chloride channels play significant roles in a variety of physiological processes including volume regulation, proliferation, differentiation, migration,apoptosis and resistance of tumor cells. Molecular identification and activation mechanisms of VSOR are poorly understood. Many signaling molecules have been shown to regulate VSOR activity in research, playing permissive or modulatory roles. Therefore, VSOR may be a new anticancer target by identifying its signaling molecules and activation mechanisms.