Defective sperm-zona pellucida interaction: a major cause of failure of fertilization in clinical in-vitro fertilization |
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| Authors: | Liu D Y Baker H W |
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| Affiliation: | University of Melbourne Department of Obstetrics and Gynaecology, Reproductive Biology Unit, Royal Women's Hospital and Melbourne IVF, Victoria, Australia. |
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| Abstract: | Sperm-zona pellucida binding and penetration were assessed on the oocytes that failed to fertilize from couples with >/=3 oocytes treated by standard in-vitro fertilization (IVF). There were four groups: fertilization rate 0% (n = 369), 1-25% (n = 194), 26-50% (n = 81) and 51-95% (n = 100). Of the couples with zero fertilization rate 70% had
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| Keywords: | IVF failure/spermatozoa/sperm– zona interaction/zona pellucida |
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