多动行为问题儿童血5-羟色胺浓度变化相关性探讨

目的探讨多动行为问题儿童与正常儿童外周血5-羟色胺浓度差别;进一步了解心理卫生偏异儿童、不同年龄阶段行为问题儿童外周血5-羟色胺浓度差别,并分析各种行为问题儿童外周血5-羟色胺浓度的变化及其意义。方法应用《Achenbach儿童行为量表》筛查并根据其因子分分类,对30例行为问题儿童进行外周血5-羟色胺含量测定,与30例正常儿童对照比较。结果多动行为问题儿童与正常儿童外周血5-羟色胺浓度比较明显降低,差异显著(P<0.05);内向型因子组与外向型因子组比较明显升高,差异显著(P<0.05);不同年龄阶段行为问题儿童外周血5-羟色胺浓度随着年龄的增长与正常儿童差异增大。结论外周血5-羟色胺浓度与行为问题有关,可能是儿童行为问题发生的物质基础之一。

To investigate the correlations of change of 5-HT levels in blood with children hyperactivity behavior problem

Objective To investigate the difference of 5 HT level between hyperactivity behavior problem children and normal children, and to study the difference of 5 HT level in the different ages of psychological health deviation ,and to analysis the change of 5 HT level in different behavior problem children and its significance.Methods Behavior deviation children were screened according to achenbach child behavior checklist(CBCL), and classified by its factor types, and the amount of 5 HT of 30 cases of behavior deviation children was determined.And a comparision was made with that of 30 cases of normal children.Result 5 HT level in serum of the hyperactivity behavior children was significantly higher than that of normal children, there was significant difference between them (P< 0.05). There were significantly higher levels in inward factor group than that in outward factor group(P< 0.05), 5 HT level were becoming increasingly higher with different ages in behavior trouble group, and the difference is becoming more distinguished with age than in normal group.Conclusion 5 HT levels in blood is related to the occurrence of children behavior trouble,it may be one of basic components contributing to behavior abnormal occurrence.