Responses of preoptic thermo sensitive neurons to mediobasal hypothalamic stimulation |
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Authors: | T. Hori T. Kiyohara T. Osaka M. Shibata T. Nakashima |
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Affiliation: | Department of Physiology, Saga Medical College, Saga 840-01, Japan |
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Abstract: | HORI, T., T. KIYOHARA, T. OSAKA, M. SHIBATA AND T. NAKASHIMA. Responses of preoptic thermosensitiveneurons to mediobasal hypothalamic stimulation. BRAIN RES. BULL. 8(6) 677–683, 1982.—Single-unit responses of preoptic-anterior hypothalamic (PO/AH) thermosensitive neurons to electrical stimulation of the mediobasal hypothalamus (MBH: ventromedial and arcuate nuclei) have been studied in urethane-anesthetized male rats. About half of thermosensitive neurons (46.4% of 69 warm-units and 50% of 28 cold-units) were initially inhibited following MBH stimulation with latencies up to 51.2 msec, while only 29.7% of 91 thermally insensitive units showed the inhibitory response. Orthodromic excitation of spontaneous activity was observed in 17.6% of the units (13.0% of warm-units, 14.3% of cold-units and 21.9% of insensitive units) with the onset latencies between 1.0 and 41.3 msec. A small proportion of neurons (5.3%) were antidromically activated by MBH stimulation, and the estimated conduction velocities of these neurons ranged from 0.11 to 0.67 m/sec. The results suggest reciprocal connections between PO/AH thermosensitive neurons and MBH, which may play some roles in thermoregulation and, also, in functional interactions between thermoregulation and other vital functions controlled in the hypothalamus. |
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Keywords: | Thermosensitive neurons Preoptic area Mediobasal hypothalamus Thermoregulation |
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