Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine. |
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| Authors: | K Starke E Borowski T Endo |
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| Affiliation: | Institute of Pharmacology, University of Essen, D-4300 Essen, Federal Republic of Germany |
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| Abstract: | Strips of the rabbit main pulmonary artery were preincubated with 3H-noradrenaline. 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation. The increase of the stimulation-evoked overflow of tritium was prevented by a high concentration of oxymetazoline. The results indicate that yohimbine is more potent in blocking the presynaptic than the postsynaptic alpha-adrenoceptors of the artery. |
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| Keywords: | Rabbit pulmonary artery Postsynaptic α-receptors Yohimbine Noradrenaline release Presynaptic α-receptors |
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