三级淋巴组织在多发性硬化中的研究进展

近年来,人们发现淋巴组织器官之外存在淋巴滤泡样结构,将其称之为异位淋巴组织,也叫三级淋巴组织。目前发现在许多疾病如多发性硬化、糖尿病、肿瘤、动脉粥样硬化和风湿性关节炎等中存在三级淋巴组织。在这里我们着重阐述三级淋巴组织形成的分子机制以及三级淋巴组织与多发性硬化(MS) / 实验性自身免疫性脑脊髓炎(EAE)疾病的关系,简述它在疾病发生发展中的作用、相关机制和研究进展,使人们对三级淋巴组织的形成和它如何参与疾病有更多的了解和认识,为临床治疗提供理论知识。

Research progress of tertiary lymphoid tissues in multiple sclerosis

In recent years,it has been found that there are lymphoid follicle structures outside the lymphoid tissues and organs,which are called ectopic lymphoid tissues,also known as tertiary lymphoid tissues (TLTs).TLTs currently have been found in a number of diseases such as multiple sclerosis,diabetes,cancer,atherosclerosis and rheumatoid arthritis and the like.Here we focus on the molecular mechanism of TLTs and the relationship between TLTs and multiple sclerosis ( MS ) / experimental autoimmune encephalomyelitis (EAE) disease,and briefly describe the role of TLTs in the development of MS/ EAE,the relevant mechanisms and research progress,make people have more understanding and insights on the formation of TLTs and the mechanism that it involved in disease,to provid theoretical knowledge for clinical treatment.