抗NMDA 受体抗体在神经精神狼疮发病机制中的研究进展

系统性红斑狼疮是一种累及全身多个器官和系统的自身免疫病,出现神经精神症状时,称为神经精神狼疮(NPSLE)。N-甲基-D-天(门)冬氨酸(NMDA)受体是一种跨膜离子通道型谷氨酸受体,抗NMDA 受体抗体主要分为抗NR1 型和抗NR2 型,近年抗NMDA 受体抗体在NPSLE 的发病机制中的作用成为一研究热点,尤其是抗NR2 抗体与NPSLE 密切相关,本文就到目前为止NMDA 抗体在NPSLE 中的作用机制的研究进展作一综述。

Research progress of mechanism of anti-NMDA-receptor antibodies in NPSLE

Systemic lupus erythematosus (SLE)is an autoimmune disease,involving multiple organs and systems,and it is defined as neuropsychiatric systemic lupus erythematosus (NPSLE)when neuropsychiatric symptoms appear.The N-methyl-D-aspartate (NMDA)receptor is a kind of membrane-spanning ion channels’glutamate receptors,which mainly contains NR1 subunit and NR2 sub-unit.In recent years,the role of anti-NMDA-receptor antibodies in the pathogenesis of NPSLE has become a research hotspot,especially for anti-NR2 antibody.Therefore we review the research progress of the mechanism of the anti-NMDA-receptor antibodies in NPSLE in this paper.