| D－半乳糖致衰老动物模型及其机制研究进展 |
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| 引用本文： | 刘建亚,冯文静,王仁萍,毛拥军.D－半乳糖致衰老动物模型及其机制研究进展[J].中华老年多器官疾病杂志,2018,17(3):224-227. |
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| 作者姓名： | 刘建亚 冯文静 王仁萍 毛拥军 |
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| 作者单位： | 青岛大学附属医院老年医学科;青岛大学附属医院体检中心; |
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| 基金项目： | 国家自然科学基金(31571829,31640050)；山东省自然科学基金(ZR2016HR23) |
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| 摘 要： | 衰老是一种正常的生理现象,年龄相关性疾病与之有密切关系,目前关于衰老机制及抗衰老药物的探索已成为该领域研究热点。衰老模型制作多样复杂,耗资巨大,因此建立一个合适的衰老模型具有尤其重要的意义。D-半乳糖诱导的亚急性衰老动物模型以其成本低廉、简便易行、结果稳定可靠等优点,已被国内外学者广泛应用。本文拟对D-半乳糖所致各种衰老动物模型及其可能机制进行简要综述。
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| 关 键 词： | 衰老 模型 动物 D－半乳糖 机制 |
| 收稿时间： | 2017/10/9 0:00:00 |
| 修稿时间： | 2017/12/28 0:00:00 |
Research progress in D-galactose-induced aging animal model and its mechanisms |
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| LIU Jian-Y,FENG Wen-Jing,WANG Ren-Ping and MAO Yong-Jun.Research progress in D-galactose-induced aging animal model and its mechanisms[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2018,17(3):224-227. |
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| Authors: | LIU Jian-Y FENG Wen-Jing WANG Ren-Ping and MAO Yong-Jun |
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| Institution: | Department of Geriatrics,,Department of Geriatrics,,Health Examination Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China and Department of Geriatrics, |
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| Abstract: | Aging is a normal physiological phenomenon, which is closely related to age-related diseases. In recent years, the mechanisms of aging and the development of anti-aging drugs have become the hotspot in scientific research. However, Establishing a suitable aging animal is complex and costly, so it is of great significance to make a suitable animal model. D-galactose-induced sub-acute aging animal model has been widely used by domestic and foreign scholars because of its advantages of low cost, simple and convenient operations, and stable and reliable results. In this review, we summarized the D-galactose-induced aging animal model and its possible mechanisms. |
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| Keywords: | aging model animal D-galactose mechanism |
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