早孕绒毛及蜕膜组织中酪氨酸磷酸酶-1 / 2( SHP-1,SHP-2) 与吲哚胺2,3-双加氧酶( IDO) 的表达及其相关性 |
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引用本文: | 袁艳,翁宇红,赵淑云,李仕祥,王珺,谭红梅,杨敏燕,黄官友.早孕绒毛及蜕膜组织中酪氨酸磷酸酶-1 / 2( SHP-1,SHP-2) 与吲哚胺2,3-双加氧酶( IDO) 的表达及其相关性[J].中国免疫学杂志,2018,34(4):513. |
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作者姓名: | 袁艳 翁宇红 赵淑云 李仕祥 王珺 谭红梅 杨敏燕 黄官友 |
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作者单位: | 贵州医科大学附属医院;贵阳市开阳县人民医院 |
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摘 要: | 目的:研究母胎界面中吲哚胺2,3-双加氧酶(IDO)及酪氨酸磷酸酶-1/2(SHP-1,SHP-2)的表达及其相关性,以探索母胎免疫耐受的新机制。方法:30 例正常早孕6 ~8 周妇女行人工流产获取绒毛及蜕膜组织,用Western blot 方法检测绒毛、蜕膜组织中的酪氨酸磷酸酶-1/2(SHP-1、SHP-2)与IDO 的蛋白表达,分析IDO 与SHP-1、SHP-2 的相关性。结果:人早孕绒毛及蜕膜组织中均有SHP-1、SHP-2 的表达,与IDO 的表达呈正相关;SHP-1、SHP-2 和IDO 在蜕膜组织中的表达均高于绒毛;结论:在正常生理妊娠状态下,母胎界面中SHP-1、SHP-2可能参与调节IDO 的表达,在维持母胎界面的免疫耐受状态起着重要作用。
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关 键 词: | 吲哚胺2 3-双加氧酶 蛋白质酪氨酸磷酸酶 绒毛 蜕膜 |
Correlation of tyrosine phosphatase-1 / 2 (SHP-1,SHP-2) with indoleamine 2,3-dioxygenase (IDO) in villi and decidua of early pregnancy |
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Abstract: | Objective: To explore the correlation of tyrosine phosphatase-1/2 ( SHP-1, SHP-2) with indoleamine 2,3-dioxygenase(IDO) in maternal fetal interface.Methods: The expression of SHP-1,SHP-2 and IDO were detected by Western blot method and the relationship of the proteins was analysed,in human chorionic villi and decidua tissues of 30 cases of artificial abortion patients.Results: The expression of SHP-1,SHP-2 were positively correlated withthe expression of IDO in human chorionic villi and decidua;the expression of SHP-1, SHP-2 and IDO in decidual tissues were higher than those in the villi.Conclusion: Normal physiological state of pregnancy,SHP-1 and SHP-2 may be involved in the regulation of immune tolerance by positive regulation of IDO expression at maternal fetal interface. |
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