| 血管通透性因子在鼻息肉中的表达及意义 |
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| 引用本文： | 杨继红,孔红.血管通透性因子在鼻息肉中的表达及意义[J].中华耳鼻咽喉科杂志,1998,33(5):297-298. |
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| 作者姓名： | 杨继红 孔红 |
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| 摘 要： | 目的 探讨血管通透性因子（ｖａｓｃｕｌａｒ ｐｅｒｍｅａｂｉｌｉｔｙ ｆａｃｔｏｒ，ＶＰＦ）在鼻息肉组织中的表达及意义。方法 将９例鼻息肉标本及８例下鼻甲粘膜标本行ＶＰＦ及其受体ｆｌｋ－１的免疫组化染色，光镜观查。结果 ＶＰＦ在鼻息肉组织的血管内皮细胞和腺体细胞的表达明显高于下鼻甲组织（Ｐ〈０．０１，Ｐ〈０．０５），ｆｌｋ－１在血管内皮细胞的表达明显高于下鼻甲组织（Ｐ〈０．０１）。结论 ＶＰＦ对鼻
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| 关 键 词： | 鼻息肉 毛细血管通透性 血管内皮 |
Expression and significance of vascular permeability factor in nasal polyps] |
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| J Yang,H Kong,Z Dong.Expression and significance of vascular permeability factor in nasal polyps][J].Chinese Journal of Otorhinolaryngology,1998,33(5):297-298. |
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| Authors: | J Yang H Kong Z Dong |
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| Institution: | Third Clinical College, Bethune University of Medical Sciences, Changchun 130031. |
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| Abstract: | OBJECTIVE: To study the expression and significance of vascular permeability factor(VPF) in nasal polyps. METHODS: Expression of VPF and its receptor flk-1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope. RESULTS: The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates (P < 0.01 and P < 0.05, respectively). The flk-1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates (P < 0.01). CONCLUSION: VPF may play a key role in the formation of heavy edema of nasal polyps. |
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