血清高敏C反应蛋白和血清降钙素原在慢性阻塞性肺疾病急性发作期中的表达及意义

目的探讨血清高敏C反应蛋白（Hs-CRP）和血清降钙素原（PCT）在慢性阻塞性肺疾病急性发作期（AECOPD）中的表达及临床意义。方法选择AECOPD患者34例，测定其治疗前后的Hs．CRP、PCT、白细胞计数（WBC）、红细胞沉降率（ESR），并做肺功能测定、BODE指数计算，分析Hs-CRP和PCT水平与BODE指数的相关性。结果Hs—CR、PCT在AECOPD中高于其他指标，治疗后变化更明显，差异有统计学意义（P〈0．01），而且与BODE指数皆呈正相关。结论Hs—CRP和PCT可作为观察AECOPD炎症状况及其控制情况的更敏感指标，可提示病情严重程度及预后情况。

The expression and significance of serum high-sensitivity C-reactive protein and serum procalcitonin in AECOPD

Objective To investigate the expression and significance of serum level of high sensitivity C-reactive protein（ Hs-CRP）and serum proealcitonin（PCT） in the patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 34 AECOPD patients who were in hospital were determined with Hs-CRP, PCT, WBC, ESR, BODE exponent before and after treatment. Besides analysis of Hs-CRP and PCT correlation with the BODE exponent. Results The serum Hs-CRP and PCT levels in the AECOPD patients was significantly higher than other indicators of the positive rate. More obvious changes after treatment（ P 〈 0.01 ）. The serum Hs-CRP and PCT leve]s in the AECOPD patients were correlated with BODE exponent. Conclusion Hs-CRP and PCT can be used as observation of AECOPD inflammatory status and its control are more sensitive indicators of the situation may he prompted to severity of disease and prognosis of the situation.