Mercury induces inflammatory mediator release from human mast cells |
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| Authors: | Duraisamy Kempuraj Shahrzad Asadi Bodi Zhang Akrivi Manola Jennifer Hogan Erika Peterson and Theoharis C Theoharides |
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| Institution: | (1) Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center, 02111 Boston, MA, USA;(2) Department of Obstetrics & Gynecology, Maternal-Fetal Medicine, Tufts University School of Medicine and Tufts, 02111 Boston, MA, USA;(3) Department of Biochemistry, Tufts University School of Medicine, 02111 Boston, MA, USA;(4) Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, 02111 Boston, MA, USA;(5) Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, 02111 Boston, MA, USA |
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| Abstract: | Background Mercury is known to be neurotoxic, but its effects on the immune system are less well known. Mast cells are involved in allergic
reactions, but also in innate and acquired immunity, as well as in inflammation. Many patients with Autism Spectrum Disorders
(ASD) have "allergic" symptoms; moreover, the prevalence of ASD in patients with mastocytosis, characterized by numerous hyperactive
mast cells in most tissues, is 10-fold higher than the general population suggesting mast cell involvement. We, therefore,
investigated the effect of mercuric chloride (HgCl2) on human mast cell activation. |
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