Phyllodes tumors of the breast: natural history, diagnosis, and treatment |
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Authors: | Telli Melinda L Horst Kathleen C Guardino Alice E Dirbas Frederick M Carlson Robert W |
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Institution: | Department of Medicine, Stanford University, Stanford, CA, USA. |
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Abstract: | Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features. The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall. Wide excision with a greater than 1 cm margin is definitive primary therapy. Adjuvant systemic therapy is of no proven value. Patients with locally recurrent disease should undergo wide excision of the recurrence with or without subsequent radiotherapy. |
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