| 雷公藤生物碱的分离鉴定 |
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| 引用本文： | 徐力红 黄丽瑛. 雷公藤生物碱的分离鉴定[J]. 中国药房, 1995, 6(4): 12-13 |
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| 作者姓名： | 徐力红 黄丽瑛 |
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| 作者单位： | 上海医科大学附属中山医院，中国科学院上海药物所 |
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| 摘 要： | 我们从雷公藤（ＴｒｉｐｔｅｒｙｇｉｕｍＷｉｌｆｏｒｄｉｉＨｏｏｋ．ｆ．）中按常法分离得到总碱后经ＨＰＬＣ分析出现８个峰，经硅胶柱层析及硅胶ＲＰ－１８反相中压柱层析分离得到５个生物碱，由化学方法和光谱分析证明为雷公藤吉碱（Ｗｉｌｆｏｒｇｉｎｅ２０）．雷公藤次碱（Ｗｉｌｆｏｒｉｎｅ２１），雷公藤春碱（Ｗｉｌｆｏｒｔｒｉｎｅ２２），雷公藤碱戊（Ｗｉｌｆｏｒｉｄｉｎｅ２３），呋喃南蛇碱（Ｃｅｌａｆｕｒｉｎｅ１６）。ＨＰＬＣ分析指出含量最高为雷公藤吉碱，其次为呋喃南蛇碱。
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| 关 键 词： | 雷公藤，雷公藤吉碱，雷公藤次碱，雷公藤春碱，雷公藤碱戊，呋喃南蛇碱，HPLC |
Isolation and Assay of the Alkaloids of Tripterygium Wilfordii Hook.f. |
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| Xu Lihong,Miao Kangli/. Isolation and Assay of the Alkaloids of Tripterygium Wilfordii Hook.f.[J]. China Pharmacy, 1995, 6(4): 12-13 |
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| Authors: | Xu Lihong Miao Kangli/ |
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| Abstract: | The total alkaloid was isolated from Tripterygium Wilfordii Hook.f.with conventional method.then analysed by HPLC,eight peaks were found.Five alkaloids were seperated from the total alkaloid w1th silica gel column chromatograpy and RP-18 medium-pressure HPLC.They were proved by chemical and spectral aalyses to be Wilforgine 20,Wilforine 21,Wilfortrine 22,Wilforidine 23 and Celafurine 16.Of them, the content of Wilforgine 20 was the highest one and that of Celafurine 16 the next. |
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| Keywords: | Tripterygium Wilforii Hook.f. Wilforgine 20 Wilforine 21 Wilfortrine 22 Wilforidine 23 Celafurine 16 |
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