| 尿8-羟基脱氧鸟苷水平与糖尿病肾病的相关性 |
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| 引用本文： | 张霞,苏本利,王赞峰,许国旺,姚庆红.尿8-羟基脱氧鸟苷水平与糖尿病肾病的相关性[J].中华糖尿病杂志,2006,14(1):41-42. |
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| 作者姓名： | 张霞 苏本利 王赞峰 许国旺 姚庆红 |
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| 作者单位： | 大连医科大学附属第二医院内分泌科，大连医科大学附属第二医院内分泌科，大连医科大学附属第二医院内分泌科，中国科学院大连化学物理研究所，中国科学院大连化学物理研究所 116027，116027，116027 |
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| 摘 要： | 正常对照32例和2型糖尿病(T2DM)患者68例,毛细管电泳法测定8-羟基脱氧鸟甘(8-OHdG)。T2DM患者与正常对照组比较,24 h尿8-OHdG水平明显升高(46±43,11±6)且随UAER的增加而增加(UAER<20μg/min组24 h尿8-OHdG含量17±9,UAER 20~200μg/min组34±22,UAER>200μg/min组80±51)。8-OHdG与糖尿病肾病(DN)程度呈正相关,偏回归系数1.09,95%CI1.02~1.17,P=0.01。
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| 关 键 词： | 糖尿病 糖尿病肾病 8-羟基脱氧鸟苷 |
| 收稿时间： | 2004-07-05 |
| 修稿时间： | 2004-07-05 |
Determination of urinary 8-hydroxy-guanine levels in diabetes mellitus and its significance in diabetic nephropathy |
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| ZHANG Xia,SU Ben-li,WANG Zan-feng,et al..Determination of urinary 8-hydroxy-guanine levels in diabetes mellitus and its significance in diabetic nephropathy[J].CHINESE JOURNAL OF DIABETES MELLITUS,2006,14(1):41-42. |
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| Authors: | ZHANG Xia SU Ben-li WANG Zan-feng |
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| Institution: | ZHANG Xia~*,SU Ben-li,WANG Zan-feng,et al.~*Department of Endocrinology,The Second Hospital,Affiliated to Dalian Medical University,Dalian 116027,China |
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| Abstract: | To explore the levels of 24 hr urinary 8-hydroxyguanine(8-OHdG)in diabetes mellitus and its association with diabetic nephropathy(DN).In 32 healthy subjects and 68 type 2 diabetic patients,8-OHdG was measured with high performance capillary electrophoresis.Urinary 8-OHdG levels were significantly higher in type 2 diabetic patients and increased with increment of urinary albumin excretion rate.The levels of 24 hr urinary 8-OHdG can evaluate the systemic oxidative stress,and the degree of 8-OHdG is correlated with the degree of DN. |
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| Keywords: | Diabetes mellitus Diabetic nephropathy 8-hydroxy-guanine |
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