Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis |
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| Authors: | G J Patskan A J Klein-Szanto J L Phillips T J Slaga |
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| Affiliation: | 1. Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia;2. Department of Anatomy and Physiology, University of Melbourne, Parkville, Victoria, Australia;3. Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy;1. SoCAT Lab Department of Psychiatry, School of Medicine Ege University, Izmir, Turkey;2. Urla State Hospital, Izmir, Turkey;3. Department of Psychology, Faculty of Letters, Dokuz Eylul University, Izmir, Turkey;4. Department of Computer Engineering, Izmir University of Economics, Izmir, Turkey |
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| Abstract: | The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo [a] pyrene (B [a] P) or N-methyl-N'-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B [a] P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys. |
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