脂肪因子与慢性心力衰竭研究进展

慢性心力衰竭的发病率和病死率高。肥胖、高血压和糖尿病等为慢性心力衰竭的传统危险因素，但近期研究表明发现肥胖的慢性心力衰竭患者预后较好，这一现象被人称为“肥胖悖论”。脂肪组织目前被认为是一种内分泌组织，分泌的多种脂肪因子可调控多种心血管功能。现综述可影响心血管功能的脂肪因子。

Advances in Research into Relationship Between Adipose Tissue and Chronic Heart Failure

Chronic heart failure （ CHF） is a progressive disease that results in substantial morbidity and mortality. The traditional cardiovascular risk factors （ for example, obesity, hypertension and diabetes, etc. ） are associated with an independently increased risk of developing CHF and mortality in the general population. Recent evidence suggests that obesity is associated with better outcomes in patients with CHF. Studies of patients with CHF that specifically examined the impact of body mass index on outcomes have suggested the existence of ＂obesity paradox＂. Adipokines represent a family of proteins released by adipocytes that affect various biological processes, including metabolism,inflammation, satiety and cardiovascular function. In this review, we highlight several recent studies that examine the pathophysiological implications of adipokines in cardiovascular pathophysiology.