| 戊四氮所致慢性癫癎大鼠海马神经元选择性凋亡的研究 |
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| 引用本文： | 何小华,王伟,阮旭中,王玉. 戊四氮所致慢性癫癎大鼠海马神经元选择性凋亡的研究[J]. 中国临床神经科学, 2002, 0(2) |
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| 作者姓名： | 何小华 王伟 阮旭中 王玉 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院神经内科 430030(何小华，王伟，阮旭中)，华中科技大学同济医学院附属同济医院神经内科 430030(王玉) |
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| 基金项目： | 国家自然科学基金重点资助项目 (No:390 0 0 4 7) |
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| 摘 要： | 目的 :探讨选择性凋亡在戊四氮所致慢性癫疒间形成中的作用。方法 :采用免疫组化及原位末端标记双标技术观察海马γ 氨基丁酸 (GABA)能神经元、谷氨酸 (Glu)能神经元各自凋亡情况。结果 :GABA能神经元凋亡数明显高于Glu能神经元凋亡数 ,两者比较有显著性差异。结论 :在癫形成期间脑内可能通过某种机制引发了细胞程序性死亡过程 ,选择性地引起GABA能神经元凋亡占优势 ,打破了兴奋与抑制性神经递质之间的平衡 ,从而促发癫
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| 关 键 词： | 癫癎 凋亡 GABA能神经元 Glu能神经元 戊四氮 |
Selective Neuron Apoptosis in Hippocampus of Epileptic Rats Induced by Pentylenetetrazol |
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| HE Xiao Hua,WANG Wei,RUAN Xu Zhong,et al.. Selective Neuron Apoptosis in Hippocampus of Epileptic Rats Induced by Pentylenetetrazol[J]. Chinese Journal of Clinical Neurosciences, 2002, 0(2) |
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| Authors: | HE Xiao Hua WANG Wei RUAN Xu Zhong et al. |
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| Affiliation: | HE Xiao Hua,WANG Wei,RUAN Xu Zhong,et al. Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Aim:To explore the role of selective neuron apoptosis in the pathogenesis of chronic epilepsy induced by pentylenetetrazol.Methods:The selective apoptosis of neurons in hippocampus of epileptic rats was observed by using double staining(immunohistochemistry and terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling)methods.Results:The amount of apoptosis of GABA ergic neuron was much higher than that of Glu ergic neuron.Conclusion:The balance of GABA ergic and Glu ergic neurons regulated by programmed cell death may be related to the pathogenesis of chronic epilepsy induced by pentylenetetrazol. |
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| Keywords: | epilepsy apoptosis GABA ergic neuron Glu ergic neuron pentylenetetrazol |
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