| HPLC法测定通脉舒胶囊中尼莫地平的含量 |
| |
| 引用本文： | 姜建国,张西如,高燕霞. HPLC法测定通脉舒胶囊中尼莫地平的含量[J]. 中国实用医药, 2009, 4(21): 67-68 |
| |
| 作者姓名： | 姜建国 张西如 高燕霞 |
| |
| 作者单位： | 河北省药品检验所,050011 |
| |
| 摘 要： | 目的建立检测制剂中尼莫地平的专属性方法。方法采用液相色谱法。选用ODSC18柱,以0.01mol/L醋酸铵（用冰醋酸调节pH值为3.5）-乙腈（30：70）为流动相,流速1.0ml/min,检测波长237nm。结果尼莫地平在进样量为0.08～0.8μg范围内线性良好（r=0.9994）,回收率为99.0%（n=6）。结论该方法选择性强,灵敏度高,可作为分析制剂中的尼莫地平。
|
| 关 键 词： | 尼莫地平 HPLC法 测定方法 液相色谱法 |
Detection of nimodipine in tongmaishu capsules by the HPLC |
| |
| JIANG Jian-guo,ZHANG Xi-ru,GAO Yan-xia. Detection of nimodipine in tongmaishu capsules by the HPLC[J]. China Practical Medical, 2009, 4(21): 67-68 |
| |
| Authors: | JIANG Jian-guo ZHANG Xi-ru GAO Yan-xia |
| |
| Affiliation: | JIANG Jian-guo, ZHANG Xi-ru, GAO Yan- xia. (Institute for Drug Control of Hebei, Hebei 050011, China ) |
| |
| Abstract: | Objective To develop a specific method for determination nimodipine . Methods The HPLC method was used. The ODS C18 column was used with amobile phase was 0. 01 mol/L ammonium acetate- solution（pH3.5）-acetonitrile（30：70）. The flow rate was 1.0 mL/min and the deterction wavaelength was 237 nm. Results The calibration curve was linear in the range of 0.08 - 0. 8 μg with r = 0. 9994. The average recovery was 99.0% （ n = 6） . Conclusion The method is selective and sensitive and can be used to detect nimodipine in Tongmaishu capsules . |
| |
| Keywords: | Nimodipine HPLC |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
