|
|||||
|
|
Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients |
|
| Authors: | Backonja Miroslav Misha Coe Christopher L Muller Daniel A Schell Kathleen |
| Affiliation: | aDepartments of Neurology, Clinical Science Center, University of Wisconsin, Madison, United States bPsychology, Clinical Science Center, University of Wisconsin, Madison, United States cRheumatology, Clinical Science Center, University of Wisconsin, Madison, United States dComprehensive Cancer Center, Clinical Science Center, University of Wisconsin, Madison, United States |
| Abstract: | This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated receptor levels for Tumor Necrosis Factor (sTNFr) were the most distinctive abnormality along with low interleukin-10 (IL-10). sTNFr in CSF and blood, and IL-1ß in CSF, were positively associated with pain intensity, whereas IL-10 in both compartments was inversely correlated with pain symptoms. An imbalance of pro- and anti-inflammatory cytokines appears to be a clinically relevant feature, which may contribute to the maintenance of chronic pain. |
| Keywords: | Neuropathy Neuropathic pain CRPS Pain intensity Cytokines Cerebrospinal Fluid Soluble Tumor Necrosis Factor receptor Interleukin-1 |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |