Pseudoviral hollow-cored vesicles in multiple sclerosis brain |
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Authors: | J. Kirk |
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Affiliation: | (1) Multiple Selerosis Research Laboratory, Department of Pathology, Queen's University and Royal Victoria Hospital, BT12 6BA Belfast, UK |
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Abstract: | Summary Novel, superficially virus-like hollow-cored particles 50–60 nm in diameter were found in the perivascular extracellular space of the brain from a patient who died with acute multiple sclerosis (MS). It is concluded that they are not virions but are derived from myelin undergoing vesicular demyelination. This case demonstrates the need for caution in the interpretation of unusual electron microscopic appearances. |
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Keywords: | Acute multiple sclerosis Virus-like particles Demyetination Electron microscopy |
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