系统性红斑狼疮患者尿新喋呤水平检测及其临床意义

用反相高效液相色谱法测定30例SLE患者尿新喋呤水平。结果表明;①SLE患者尿新喋呤水平明显增高。②SLE患者尿新喋呤水平与疾病活动性呈显着正相关,随临床治疗有效、疾病活动性下降,尿新喋呤水平下降。③尿新喋呤水平与血沉呈显着正相关,与ANA、抗ds-DNA抗体、补体C3间无相关关系。分析表明原新喋呤可作为判断SLE疾病活动性及临床疗效的指标。

Detection of Urinary Neopterin in Patients with Systemic Lupus Erythematosus and tis Clinical Significance

The levels of urinary neopterin in 30 patients with SLE were determined by reversed-phase high performance liquid chromatgraphy(HPLC). The results showed: (1 ) the levels of urinary neopterin in 30 patients with SLE were significantly higher than those in 20 controls. (2) The concentrations of urinary neopterin in SLE patients were significantly correlated with the disease activity, they decreased after efficacious treatment with reduced disease activity. (3) There was significant positive correlation between urinary neopterin concentration and erythrocyte sedimentation rate, but there were no statistical relations between urinary neopterin levels and ANA, antibody to ds-DNA, or plasma C3 levels. These results indicate that urinary neopterin may be used as an index for the assessment of disease activity in patients with SLE and monitoring therapeutic effect.