| 健康汉族人细胞色素P450 2C19基因的检测 |
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| 引用本文： | 张惠文 陈盛强. 健康汉族人细胞色素P450 2C19基因的检测[J]. 现代临床医学生物工程学杂志, 2002, 8(4): 261-262 |
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| 作者姓名： | 张惠文 陈盛强 |
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| 作者单位： | [1]广东省中医院 [2]广州医学院神经科学研究所，广州5100000 |
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| 摘 要： | 目的：了解广东地区汉族人细胞色素（P450 2C19）基因的分布情况。方法：应用PCR技术对正常人细胞色素（P450 2C19）基因进行扩增以SmaI进行限制性酶切图谱分析。结果：广东地区汉族人P450 2C19基因中，野生型纯合子（wt/wt）频率是0.4454；CYP2C19杂合子（mt/ml）频率是0.4091；CYP2C19突变型纯合子（ml/ml）频率是0.1455。P450 2C19基因ml频率是0.3500，基因wt频率是0.6500。结论：广东地区汉族人的细胞色素CYP2C19基因频率与其它地区人群相接近。
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| 关 键 词： | 健康汉族人 细胞色素P450 2C19 PCR 基因检测 药物遗传学 限制性酶切图谱 |
| 文章编号： | 1008-634X(2002)04-0261-02 |
| 修稿时间： | 2002-04-23 |
Detection of P450 2C19 in the Hans of Guangdong |
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| ZHANG Wui wen,CHEN Sheng qiang. Detection of P450 2C19 in the Hans of Guangdong[J]. Journal of Modern Clinical Medical Bioengineering, 2002, 8(4): 261-262 |
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| Authors: | ZHANG Wui wen CHEN Sheng qiang |
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| Abstract: | Objective To identify the distribution feature of P450 2C19 gene in hans in Guangdong Province. Method P450 2C19 genes from normal individuals were amplified with PCR and their restricted enzyme digested maps analysis were done with SmaI. Results Genotypefrequency:P450 2C19 wt/wt 0.4454;P450 2C19 wt/ml 0.4091;P450 2C19 ml/ml 0.1455;P450 2C19 Genefrequenc:P450 2C19wt 0.6500;P450 2C19ml 0.3500. Conclusion The P450 2C19 genes distrbution in the Hans in Guangdong province is similar to those in other areas. |
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| Keywords: | P450 2C19 Genetic polymorphism |
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