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大承气汤抗急性坏死性胰腺炎肺损伤的实验研究
引用本文:夏庆,龚旭,蒋俊明,陈光远,黄宗文. 大承气汤抗急性坏死性胰腺炎肺损伤的实验研究[J]. 四川大学学报(医学版), 1999, 30(4): 0
作者姓名:夏庆  龚旭  蒋俊明  陈光远  黄宗文
作者单位:华西医科大学附属第一医院,中医科,成都,610041
基金项目:国家中医药管理局“八五”重点基金!(资助号H09301)
摘    要:为研究急性坏死性胰腺炎(ANP)早期白细胞粘附强弱和肿瘤坏死因子(TNF)的变化及其与肺损伤的关系,以及大承气汤能否减轻肺损伤的程度,将14 只家犬随机分成承气汤组(n= 5,ANP模型+ 大承气汤治疗),盐水组(n= 5,ANP模型+ 生理盐水治疗)和假手术组(n= 4)3 组。术后在流室系统下观察白细胞与内皮细胞的粘附强弱,并测定血清及支气管肺泡灌洗液(BALF)TNF活性和肺损伤程度。结果显示:实验犬ANP时白细胞粘附活性增强,外周血及BALF中TNF活性升高;承气汤组白细胞粘附活性低于盐水组(P< 0.05),血清及BALF的TNF活性低于盐水组(P< 0.01);承气汤组肺损伤程度轻于盐水组。结果提示:白细胞粘附和TNF的过度分泌参与ANP病理生理及肺损伤的发生,大承气汤能够减轻二者介导的肺损伤。

关 键 词:急性胰腺炎  肺损伤  细胞粘附  肿瘤坏死因子  大承气汤

Experimental Study of tachengchi tang Decoction for Relieving Lung Injury During Acute Necrotizing Pancreatitis
Xia Qing,Gong Xu,Jiang Junming,Chen Guangyuan,Huang Zongwen. Experimental Study of tachengchi tang Decoction for Relieving Lung Injury During Acute Necrotizing Pancreatitis[J]. Journal of Sichuan University. Medical science edition, 1999, 30(4): 0
Authors:Xia Qing  Gong Xu  Jiang Junming  Chen Guangyuan  Huang Zongwen
Abstract:The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor (TNF) in the early stage of acute necrotizing pancreatitis (ANP),to go further into the relation of those changes to lung injury of ANP,and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte abhesion and TNF secretion. 14 canines were randomly divided into 3 groups.The treatment group ( n =5):experimental ANP model treated with ta chengchi tang Decoction;the saline control group ( n =5):experimental ANP model treated with normal saline;and the sham operative group ( n =4) The adhesion of leukocytes to vascular endothelial cells and TNF activities in serum and in bronchi alveolar lavage fluid (BALF)were observed and measured,and the degrees of lung injury were assessed. The results showed that the adhesiveness of leukocytes was markedly increased and the activities of TNF were elevated in peripheral blood and BALF during ANP;that the leukocyte adhesiveness in the treatment group was weaker than that in the saline group ( P <0.05) and the serum and BALF TNF activities were also significantly lower than those in the saline group ( P <0.01);and that the degrees of lung injury in the treatment group were significantly milder than those in the saline group.These indicate that the increased leukocyte adhesiveness and hypersecretion of TNF take part in the pathogenesis of lung injury in ANP,and ta chengchi tang Decoction is demonstrated an efficacious medicine for alleviating the degree of lung injury mediated by both the leukocyte adhesion and TNF in ANP.
Keywords:Acute pancreatitis Lung injury Leukocyte adhesiveness Tumor necrosis factor ta chengchi tang Decoction
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