| 单克隆抗体HIP_2对人CFU－GM及CFU－AML体外作用的研究 |
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| 引用本文： | 施红,严文伟,韩俊领,邱录贵. 单克隆抗体HIP_2对人CFU－GM及CFU－AML体外作用的研究[J]. 中华血液学杂志, 1994, 0(5) |
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| 作者姓名： | 施红 严文伟 韩俊领 邱录贵 |
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| 作者单位： | 中国医学科学院协和医科大学血液病医院 |
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| 摘 要： | 刺激型抗人血小板单克隆抗体──ＨＩＰ_２在体外有刺激人造血祖细胞集落形成的作用。本研究结果显示：ＨＩＰ_２对正常人和急性髓系白血病（ＡＭＬ）初诊及缓解患者的粒单系造血祖细胞（ＣＦＵ－ＧＭ）集落产率有明显刺激作用，而对ＡＭＬ祖细胞（ＣＦＵ－ＡＭＬ）集落产率无明显刺激作用，为临床ＡＭＬ患者在化疗抑制期及骨髓移植造血抑制期用该抗体加速造血恢复提供了实验依据。
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| 关 键 词： | 抗体，单克隆，粒单系造血祖细胞，白血病祖细胞，白血病，髓细胞性，急性 |
STUDY ON THE ROLE OF MoAb-HIP_2 lN GRANULOCYTE-MACROPHAGE PROGENlTORS AND ACUTE MYELOlDLEUKEMlA PROGENlTORS lN VlTRO |
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| Shi Hong,Yan Wenwei,Han Junjing,et al. STUDY ON THE ROLE OF MoAb-HIP_2 lN GRANULOCYTE-MACROPHAGE PROGENlTORS AND ACUTE MYELOlDLEUKEMlA PROGENlTORS lN VlTRO[J]. Chinese Journal of Hematology, 1994, 0(5) |
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| Authors: | Shi Hong Yan Wenwei Han Junjing et al |
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| Abstract: | cAb HIP_2 had been shown to stimulate colony for-mation of hematopoietic progenitors in vitro.Our resultsindicated that HIP_2 significantly stimulated granulocyte-macrophage progenitors colony formation in normal indi-viduals;acute myeloid leukemia(AML)patients at di-agnosis and in complete remission,but rarely stimulatedthe growth of AML progenitors.The data implied thatHIP_2 could be used to accelerate the recovery ofhematopoiesis during myelogenic aplasia afterchemotherapy and bone marrow transplantation. |
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| Keywords: | Monoclonal antibody Granulocyte-macrophage progenitors Myeloidleukemia progenitors Acute Non-lymphoblastic leukemia |
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