Intraoperative liposomal bupivacaine for skin graft donor site analgesia: A retrospective cohort study |
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| Institution: | 1. Department of Surgery, University of South Alabama Medical Center, 2451 USA Medical Center Dr, Suite 10-I, Mobile, AL 36617, United States;2. Department of Surgery, Medical University of South Carolina, 96 Jonathan Lucas St, CSB420/MSC613, Charleston, SC 29425, United States;3. Department of Pharmacy Practice, Auburn University, Harrison School of Pharmacy, 650 Clinic Drive, Suite 2100, Mobile, AL 36688, United States;1. Department of General Surgery, Motahari Burn Research Center, Iran University of Medical Sciences, Tehran, Iran;2. Department of General Surgery, Rasoul-e-Akram General Hospital, Iran University of Medical Sciences, Tehran, Iran;1. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia;2. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt;3. Department of Rehabilitation Sciences, Faculty of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia;4. Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt;5. Department of Physiotherapy, Center of Radiation Oncology & Nuclear Medicine, Cairo University, Giza, Egypt;6. Department of Physical Therapy for Women’s Health, Faculty of Physical Therapy, Cairo University, Giza, Egypt;7. Department of Physical Therapy, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia;8. Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt;1. Peking University Fourth School of Clinical Medicine, Xinjiekoudongjie Street 31, Xicheng District, Beijing, 100035, PR China;2. Department of Burns, Beijing Jishuitan Hospital, Xinjiekoudongjie Street 31, Xicheng District, Beijing, 100035, PR China |
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| Abstract: | IntroductionBurn injury and reconstructive operations often result in severe pain, particularly at skin graft donor sites. Traditional local anesthetics administered intraoperatively control pain at donor sites, but the duration of action is short. Liposomal bupivacaine, a novel local anesthetic, can provide sustained-release analgesia for 72 h. The primary aim of this study was to describe the efficacy of liposomal bupivacaine for postoperative donor site pain control for patients undergoing skin graft procedures.MethodsA retrospective cohort study was performed on patients who received a donor site liposomal bupivacaine field block and was compared to a matched control. Patients rated donor site pain on post-operative day 0 and 1, and stated whether the donor or graft site was more painful.ResultsFifty-eight patients were included. Twenty-nine patients received liposomal bupivacaine. Eighty-six percent of patients in the treatment group rated donor site pain as three or less on postoperative day 0 and 1, compared to 3.4% in the control (p < 0.0001). Also, 76% of patients in the treatment group stated donor site pain was less than graft site pain, compared to 3.4% in the control (p < 0.0001).ConclusionPatients who received liposomal bupivacaine reported less postoperative donor site pain and found the donor site to be less bothersome without major complications. Liposomal bupivacaine may be a safe and promising agent for prolonging postoperative analgesia and minimizing donor site pain. |
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| Keywords: | Liposomal bupivacaine Exparel Skin graft analgesia Burn analgesia Burn pain control Donor site analgesia |
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