Similar impact and replacement disease after pneumococcal conjugate vaccine introduction in hospitalised children with invasive pneumococcal disease in Europe and North America |
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| Institution: | 1. Department of Public Health Solutions, Finnish Institute for Health and Welfare, Tampere, Finland;2. Department of Social and Preventive Medicine, Laval University, Quebec City, Canada;3. Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland;4. Department of Infectious Disease Epidemiology, Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, UK;5. Paediatric Infectious Diseases Research Group, St. George’s University of London, London, UK;6. Quebec University Hospital Research Centre, Quebec City, Canada;7. Center of Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands;8. Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, the Netherlands |
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| Abstract: | High incidence of childhood invasive pneumococcal disease (IPD) in the US declined steeply after 7-valent pneumococcal conjugate vaccine (PCV7) introduction, outweighing reductions observed elsewhere. We re-analysed aggregate published data and compared pre- and post-PCV IPD-incidence in different countries to explore PCV impact on hospitalised and outpatient IPD separately. The proportion of hospitalised IPD cases was consistently high (>80%) in England&Wales, Finland, the Netherlands, and Quebec/Canada, but only 32% in the US before PCV introduction, increasing to 69% during the PCV era. In the US, a higher reduction in outpatient IPD incidence (94% in 2015 versus 1998–99) was observed compared to hospitalised IPD (79%); a 51% reduction in the non-PCV13-type IPD incidence among outpatient cases was estimated compared to a >2-fold increase for hospitalised cases. After stratification by hospitalization status, PCV programmes resulted in similar impact and serotype replacement in hospitalised IPD in US when compared to other countries. |
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| Keywords: | Vaccination Streptococcus pneumoniae Conjugate vaccines Surveillance Bias PCV"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"pneumococcal conjugate vaccine IPD"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"invasive pneumococcal diseases |
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