支气管哮喘患儿诱导痰嗜酸粒细胞与肺功能及FeNO浓度的关系

目的探讨支气管哮喘(哮喘)患儿诱导痰嗜酸粒细胞(EOS)与肺功能及呼出气一氧化氮(FeNO)浓度的关系。方法回顾分析了2016年10月至2018年12月在海南省妇女儿童医学中心儿科就诊的哮喘患儿共113例的病例资料,纳入观察组;将同期在海南省妇女儿童医学中心体检的50例健康儿童纳入对照组。分别检测2组受试者的诱导痰EOS、第1秒用力呼气容积占预计值百分比(FEV1%pred)以及FeNO水平并进行相关分析。结果观察组患儿诱导痰EOS和FeNO水平显著高于对照组(t=11.921、17.081,P值均<0.05),而其FEV1%pred较对照组差,差异有统计学意义(t=18.673,P<0.05)。针对观察组患儿的相关数据进行分析,发现FeNO与痰EOS水平呈正相关(r=0.265,P=0.005)。肺功能FEV1%pred与痰EOS水平无明显相关性(r=0.158,P=0.093)。结论哮喘患儿诱导痰EOS水平与FeNO呈正相关,但与肺功能无明显相关性。

Relationship between sputum eosinophils and lung function,fractional exhaled nitric oxide concentration in children with bronchial asthma

Objective To explore the relationship between sputum eosinophils count(EOS)and lung function,fractional exhaled nitric oxide(FeNO)concentration in children with bronchial asthma(asthma).Methods A total of 113 children with asthma in Hainan Women and Children′s Medical Center from October 2016 to December 2018 was retrospectively enrolled in the observation group.Meanwhile,50 healthy children who had physical examination in Hainan Women and Children′s Medical Center in the same period were assigned into the control group.The induced sputum EOS,forced expiratory volume in one second as a percentage of expected value(FEV1%pred)and FeNO levels of two groups were detected and analyzed.Results The level of induced sputum EOS and FeNO in the observation group was significantly higher than that of in the control group(t=11.921,17.081,both P<0.05).And the FEV1%pred of the observation group was much lower than that of in the control group(t=18.673,P<0.05).To further analyze the data of children with asthma,a positive correlation between FeNO and sputum EOS was observed(r=0.265,P=0.005),but there was no correlation between FEV1%pred and sputum EOS(r=0.158,P=0.093).Conclusions In children with asthma,there is a positive correlation between FeNO and sputum EOS,but no correlation between FEV1%pred and sputum EOS.