NIH funding for vaccine readiness before the COVID-19 pandemic |
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Affiliation: | 1. Department of Natural & Applied Sciences, Bentley University, Waltham, MA 02452, United States;2. Center for Integration of Science and Industry, Bentley University, Waltham, MA 02452, United States;3. Department of Mathematical Sciences, Bentley University, Waltham, MA 02452, United States;4. Department of Management, Bentley University, Waltham, MA 02452, United States |
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Abstract: | Rapid development of vaccines for COVID-19 has relied on the application of existing vaccine technologies. This work examines the maturity of ten technologies employed in candidate vaccines (as of July 2020) and NIH funding for published research on these technologies from 2000–2019. These technologies vary from established platforms, which have been used successfully in approved products, to emerging technologies with no prior clinical validation. A robust body of published research on vaccine technologies was supported by 16,358 fiscal years of NIH funding totaling $17.2 billion from 2000–2019. During this period, NIH funding for published vaccine research against specific pandemic threats such as coronavirus, Zika, Ebola, and dengue was not sustained. NIH funding contributed substantially to the advance of technologies available for rapid development of COVID-19 vaccines, suggesting the importance of sustained public sector funding for foundational technologies in the rapid response to emerging public health threats. |
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Keywords: | NIH Funding Vaccine COVID-19 SARS-CoV-2 CEPI" },{" #name" :" keyword" ," $" :{" id" :" k0030" }," $$" :[{" #name" :" text" ," _" :" Coalition for Epidemic Preparedness Innovations MeSH" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" Medical Subject Headings WHO" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" World Health Organization PMID" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" PubMed Identifiers TLR9" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" toll-like receptor 9 TIME" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" Technology Innovation Maturation Evaluation (model) RePORT" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" (NIH) Research Portfolio Online Reporting Tools |
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