Malignant transformation in a cohort of patients with oral epithelial dysplasia |
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| Affiliation: | 1. Unit of Oral and Maxillofacial Pathology, The School of Clinical Dentistry, Claremont Crescent, Sheffield S10 2TA, UK;2. Department of Oral and Maxillofacial Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK;1. Department of Oral and Maxillofacial Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, United Kingdom;2. Regional Maxillofacial Unit, Aintree University Hospital, Lower Lane, Liverpool L9 7AL, United Kingdom;1. Department of Orthodontics, School of Dentistry, Universidad Autónoma de Yucatán, Calle 61-A No. 492-A Costado Sur del Parque de la Paz por Avenida Itzáes, Col. Centro, 97000, Mérida, Yucatan, Mexico;2. School of Dentistry, Universidad Autónoma de Aguascalientes, Edif. 101, Ciudad Universitaria Av. Aguascalientes No. 904, Unidad Médico Didáctica, Aguascalientes, Ags., 20131, Mexico;3. Department of Periodontics, School of Dentistry, Universidad Autónoma de Yucatán, Calle 61-A No. 492-A Costado Sur del Parque de la Paz por Avenida Itzáes, Col. Centro, 97000, Mérida, Yucatan, Mexico;1. Oral and Maxillofacial Surgery Department, Queen Elizabeth University Hospital Glasgow, United Kingdom;2. University of Glasgow Medical School, Faculty of Life Sciences, United Kingdom;3. BAOMS Royal College of Surgeons of England, 35/43 Lincoln''s Inn Fields, London, United Kingdom;1. Royal Perth Hospital, Perth, Western Australia, Australia;2. School of Public Health, University of Queensland, Brisbane, Queensland, Australia;3. Fiona Stanley Hospital, Perth, Western Australia, Australia;4. The Canberra Hospital, Canberra, Australian Capital Territory, Australia;1. Bartshealth NHS Trust, Royal London Hospital, Whitechapel, London, UK;2. Queen Mary University of London, UK;3. Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, Freiburgstrasse 4, 3010 Bern, Switzerland |
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| Abstract: | Oral epithelial dysplasia (OED) is often diagnosed in oral potentially malignant disorders (OPMD) and carries an increased risk of malignant transformation. Currently, the reported risk of malignant transformation for OED varies. Here we present the risk in a cohort of 150 patients with OED at a specialist centre. In this cohort 2.6%, 4.1%, and 29.2% cases of mild, moderate, and severe OED, respectively, progressed to oral squamous cell carcinoma at the dysplastic site, while a small number developed a malignant lesion elsewhere. Moreover, 17 patients experienced an increase in grade of dysplasia and two showed histological resolution of their lesions. |
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| Keywords: | Malignant transformation oral epithelial dysplasia oral potentially malignant disorders |
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