Caudal ventrolateral medulla |
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Authors: | T Kubo H Amano Y Misu |
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Institution: | (1) Department of Pharmacology, Yokohama City University School of Medicine, Urafunecho, Minami-ku, 232 Yokohama, Japan |
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Abstract: | Summary We localized glutamate-sensitive sites in the ventrolateral medulla of the rat with the spinal cord cut at C1. When unilaterally injected into a circumscribed region of the caudal ventrolateral medulla,l-glutamate (30–300 ng) elicited a dose-dependent increase in arterial pressure. The pressor response was accounted for by an increased release of vasopressin because it was abolished by the intravenous injection of a vasopressin antagonist. Bilateral microinjections of kainic acid (50 ng) into the ventrolateral glutamate-sensitive area markedly reduced a vasopressin-induced pressor response to kainic acid (30 ng), injected bilaterally into the nucleus tractus solitarii. It is concluded that the glutamate-sensitive neurons in the caudal ventrolateral medulla are involved in mediation of the vasopressin-induced pressor response arising from the nucleus tractus solitarii. |
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Keywords: | Ventrolateral medulla Spinal transection Pressor response Glutamate Kainic acid Vasopressin antagonist |
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